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Coeliac disease

A person with coeliac disease has a bad reaction to gluten in food and drink.

Coeliac disease isn't a food allergy or intolerance. It is an autoimmune condition where the body's immune system attacks its own healthy tissue in the small bowel when gluten is eaten.

Gluten is a protein found in wheat, rye and barley cereal.

If a person with coeliac disease eats gluten, symptoms include diarrhoea, bloating, flatulence, stomach pain, and fatigue. Over time there may be unplanned weight loss and children may not grow at a normal rate.

There is no cure for coeliac disease but it can be managed or treated by sticking to a gluten-free diet.

What causes coeliac disease?

Normally, the body's immune system is designed to protect it from foreign invaders. When people with coeliac disease eat foods containing gluten, their immune system forms antibodies to gluten that then attack the intestinal lining. This causes inflammation in the intestines and damages the villi, the hair-like structures on the lining of the small intestine. Nutrients from food are absorbed by the villi. If the villi are damaged, the person cannot absorb nutrients and ends up malnourished, no matter how much he or she eats.

What are the symptoms of coeliac disease?

Symptoms of coeliac disease vary and include:

  • Digestive problems: abdominal bloating, pain, wind, diarrhoea, pale stools
  • Vomiting
  • Weight loss
  • Growth problems and failure to thrive in children
  • Tingling sensation in the legs caused by nerve damage and low calcium
  • Mouth ulcers
  • Limb swelling (oedema)
  • Tiredness, faintness, or fatigue, due to anaemia


What health problems accompany coeliac disease?

Coeliac disease can leave a person susceptible to other health problems, including:

People who have celiac disease may have other autoimmune diseases, including:

How is coeliac disease diagnosed?

If your doctor suspects you have coeliac disease, he or she will perform a careful physical examination and will discuss your medical history with you. He or she may also perform a blood test to measure for higher levels of certain types of antibodies (substances produced by the immune system to fight harmful invaders) found in people with coeliac disease.

Your doctor may perform other tests to detect nutritional deficiencies, such as a blood test to detect iron levels; a low level of iron (which can cause anaemia) can occur with coeliac disease. A stool sample may be tested to detect fat in the stool, since coeliac disease prevents fat from being absorbed from food.

Your doctor may arrange for you to have a biopsy from your small intestine to check for damage to the villi. In a biopsy, the doctor inserts an endoscope (a thin, hollow tube) through your mouth and into the small intestine, and takes a sample of the small intestine with an instrument to examine under a microscope.

WebMD Medical Reference

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