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Causes of rhesus disease

NHS Choices Medical Reference

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Rhesus disease is caused by a specific mix of blood types between a pregnant mother and her unborn baby.

Rhesus disease can only occur if:

  • the mother has a rhesus negative (RhD negative) blood type
  • the baby has a rhesus positive (RhD positive) blood type
  • the mother has previously been exposed to RhD positive blood and has developed an immune response to it (known as sensitisation)

These are explained in more detail below.

Blood types

There are several different types of human blood known as blood groups with the four main ones being A, B, AB and O. Each of these blood groups can either be RhD positive or negative.

Whether someone is RhD positive or RhD negative is determined by the presence of the rhesus D (RhD) antigen. This is a molecule found on the surface of red blood cells.

People who have the RhD antigen are RhD positive, and those without it are RhD negative. In the UK, around 85% of the population are RhD positive.

How blood types are inherited

Your blood type depends on the genes you inherit from your parents. Whether you are RhD positive or negative depends on how many copies of the RhD antigen you have inherited. You can inherit one copy of the RhD antigen from your mother or father, a copy from both of them, or none at all.

You will only have RhD negative blood if you don't inherit any copies of the RhD antigen from your parents.

A woman with RhD negative blood can have an RhD positive baby if her partner's blood type is RhD positive. If the father has two copies of the RhD antigen, the baby will have RhD positive blood. If the father only has one copy of the RhD antigen, there is a 50% chance of the baby being RhD positive.


An RhD positive baby will only have rhesus disease if their RhD negative mother has been sensitised to RhD positive blood. Sensitisation occurs when the mother is exposed to RhD positive blood for the first time and develops an immune response to it.

During the immune response, the woman's body recognises that the RhD positive blood cells are foreign and creates antibodies to destroy them.

In most cases, these antibodies are not produced quickly enough to harm a baby during the mother's first pregnancy. Instead, any RhD positive babies the mother has in the future are most at risk.

How does sensitisation occur?

During pregnancy, sensitisation can happen if:

  • small numbers of foetal blood cells cross into the mother's blood
  • the mother is exposed to her baby's blood during delivery
  • there has been bleeding in the pregnancy
  • an invasive procedure has been necessary during pregnancy - such as amniocentesis, or chorionic villus sampling (CVS)
  • the mother injures her abdomen (tummy)

Sensitisation can also occur after a previous miscarriage or ectopic pregnancy, or if an RhD negative woman has received a transfusion of RhD positive blood by mistake (although this is extremely rare).

How sensitisation leads to rhesus disease

If sensitisation occurs, the next time the woman is exposed to RhD positive blood her body will produce antibodies immediately.

If she is pregnant with an RhD-positive baby, the antibodies can lead to rhesus disease when they cross the placenta and start attacking the baby's red blood cells.

Medical Review: June 29, 2013

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