BMJ Group Medical Reference
You can try decongestants for sinusitis, but we don't know if they work. Decongestants come as pills and nasal sprays. They aim to reduce the swelling inside your nose so you can breathe more easily. Common decongestants (and their brand names) are pseudoephedrine pills (Sudafed), oxymetazoline (Vicks Sinex), phenylephrine (Fenox), and xylometazoline (Otrivine).
You should not use decongestant nasal sprays for longer than a week. After that they can cause rebound congestion, which means they can make the problem worse after you stop taking them.
Decongestants are not suitable for some people. If you have heart disease, diabetes, or a thyroid condition, talk to your doctor before taking a decongestant.
Some decongestant sprays may irritate the lining of your nose and cause headaches and nausea.
Pseudoephedrine can make your heart race, and it can also cause restless feelings and sleep problems.
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