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Depression health centre

Common causes of depression

Health experts' understanding of depression has come a long way in the last few decades. In many cases, depression doesn't have just one cause. It often results from a mixture of biology, psychology, and stressful or traumatic events.

Reasons for depression include:

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When you lose someone or something dear to you, it's natural to feel pain and grief. The grief process is a very normal response, and most people experience it. But when grief encompasses your life and you begin to feel hopeless, helpless, and worthless, then it's time to talk to your doctor about grief and depression.

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  • Biology. Researchers still have a lot to learn about exactly why people become depressed. Some experts say depression often results from an imbalance of certain chemicals in the brain. These chemicals are called neurotransmitters. Antidepressants work by acting on the levels of these chemicals and bringing them back into balance.
  • There's also a genetic connection. If depression runs in your family, you have a higher chance of becoming depressed.
  • Other general health conditions or diseases can increase your risk of depression. For instance, if you have a heart attack, you have a 65% risk of becoming depressed afterwards. Conditions such as cancer, heart disease, thyroid problems and many others increase your risk of becoming depressed. Even a viral illness like influenza can bring on depression in some people.
  • Your gender makes a difference too. Women are about twice as likely as men to become depressed. No one is sure why, but the hormonal changes that women go through at different times of their lives may be a factor.
  • Psychology. Studies show that people who have a pessimistic personality are more likely to become depressed. This doesn't mean that a ‘better attitude’ will resolve your depression.
  • Stressful events. Many people become depressed during difficult times. Losing a family member or close friend, being diagnosed with a serious illness, going through a divorce, or any other traumatic event may trigger depression.
  • Medication and substances. Many prescription medicines can cause symptoms of depression. Alcohol or substance abuse is common in depressed people. It often makes their condition worse.

Some people have a clear sense of why they become depressed. Others don't. The most important thing to remember is that depression is not your fault. It is not a flaw in your character. It's a disease that can affect anyone.

WebMD Medical Reference

Medically Reviewed by Dr Keith David Barnard on July 08, 2009

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