BMJ Group Medical Reference
Isotretinoin (brand name Isotrex) is a retinoid (a chemical that comes from vitamin A). It is similar to the retinoid tretinoin. It is available only on prescription from a doctor. If you use isotretinoin gel regularly, it can improve the appearance of your skin. But it can cause unpleasant side effects.  
In one study:
More than 5 in 10 people using isotretinoin got peeling skin
Just under 5 in 10 got itching
Up to 7 in 10 got a burning sensation on their skin
Up to 1 in 10 had severe skin reactions.
For some people, the side effects of isotretinoin are so bad they stop using it.  
If you're pregnant, using isotretinoin could harm your baby.  If there's a chance you could become pregnant, make sure you use contraception.
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