Antifungals to treat oral thrush in children
BMJ Group Medical Reference
The treatment normally used for oral thrush is antifungal medicine. There is good research showing that this treatment works in babies and children.
Antifungal drugs used to treat existing oral thrush include:
Fluconazole liquid (brand name Diflucan) to swirl around your mouth and swallow
Miconazole gel (brand name Daktarin) to smear on infected places in your mouth
Nystatin liquid (brand name Nystan) that you swirl around your mouth.
There has been some good research to show that these medicines work to get rid of thrush. Miconazole and fluconazole seem to work better than nystatin. One large study found that nearly all the children with oral thrush who were otherwise healthy got rid of the infection after using miconazole gel for 12 days.  Only 1 in 2 children who used nystatin liquid were cured.
In another study, all the babies treated with fluconazole liquid were cured after seven days.  Out of those treated with nystatin, only 1 in 3 were cured.
Another large study looked at children who had oral thrush because their immune system wasn't working properly. It found that 9 in 10 children were cured after being treated with fluconazole liquid.  One in 2 of those treated with nystatin liquid were cured.
In studies, the most common side effects of antifungal medicines were vomiting and diarrhoea. But fewer than 5 in 100 children got these problems.  
Your immune system is made up of the parts of your body that fight infection. When bacteria or viruses get into your body, it's your immune system that kills them. Antibodies and white blood cells are part of your immune system. They travel in your blood and attack bacteria, viruses and other things that could damage your body.
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